THE PURRFECT CATTERY
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Polycystic Kidney Disease Information
Polycystic Kidney Disease also know as PKD which is an autosomal dominant disorder that mostly affects Exotics, British Shorthairs, Scottish Folds, Persians, and Himalayans. PKD forms Cyst on the kidneys and problems occur when the cysts start to grow fast which make the kidneys larger and larger. These cysts are present from birth and can be anywhere from under one millimeter to several centimeters. As the kidneys grow larger and larger the cysts will sometimes also grown larger and this starts to cause the kidneys to not function properly, which eventually causes kidney failure. PKD will also eventually lead to renal failure, and could even cause death. This disease is inherited but one parent must have the PKD1 mutation for it to be passed down to their offspring. PKD is likely to affect offspring 50% of the time.
PKD progresses slowly and is a late onset disease. Usually you will start to see signs of PKD around 7 years of age but that doesn't mean your cat cannot exceed a life span of 7 years old. Signs of PKD are weight loss, drinking a large quantity of water, excessive urination, lack of appetite, and depression. Not all cats who have PKD will die of the disease, sometimes the cat will die before kidney failure.
It is said that about 37% of the Persian breed have PKD1. PKD can be detected with ultrasound but has been proven that testing with ultrasound is very inaccurate. Some owners and breeders found out through ultrasound that their cat was PKD negative, but later in life found out that their cat actually did have the PKD1 mutation. With in the last year UC Davis has come up with a way to test for PKD with DNA which is 100% accurate. Kittens can be tested as early as 8 weeks of age.
Any body can collect a DNA sample from their cat or kitten. Cheek swabs are provided and what you do with it is twirl the swabs on the inside of the cat or kittens cheek to collect loose cheek cells. It is very simple and causes no pain to your cat or kitten.
PKD genotypes are N (normal allele), P (PKD mutation), N/N (two normal copies of the gene), N/P (one normal copy, one copy of the PKD mutation), and P/P (two copies of the PKD mutation). Kittens that have the genotype P/P will most likely die in utero or they are born stillborn. The genotype N/N means your kitten or cat is PKD negative. And the genotype N/P means that they have one allele for the PKD mutation. The percentages of N/P are 25% is normal, 25% negative (N/N), and 50% has one normal copy, and one copy of the PKD mutation. A breeder Cat should not be bred unless they are 100 percent PKD negative.
PKD has actually been reported since about 1967 which is almost 40 years but unbelievably is not as well know as it should be. It is important for any body who has these breeds to make sure that their cat is tested for PKD. There is no known cure for PKD the only thing that we can do to help lessen this disease is hope that breeders are responsible and spay and neuter any cat that comes back with a result other than N/N(negative). As a breeder I feel it is my responsibility to educate the people about PKD and would never breed any cat with a result other than N/N(negative).
I am proud to say that I am a PKD NEGATIVE CATTERY! All of my breeders have been DNA tested PKD NEGATIVE! Therefor all of my kittens will have a genotype of N/N which means they will all be PKD NEGATIVE!
For any further questions or to see copies of my cats results please e-mail me at PurrfectCattery@aol.com and I will get back to you with in the next 24-48 hours. Thank you for your time and I hope this helps you better understand Polycystic Kidney Disease.